What is multiple miscarriage and why do you need to know about it?

A “miscarriage” is the involuntary termination of pregnancy. Roughly one of eight pregnancies ends with a miscarriage. Most cases occur during the first trimester and it is the most common complication of early pregnancy.

Miscarriages were referred to as “recurrent” when it involves three or more consecutive failed pregnancies, usually before 20 weeks of gestations. Recently, experts redefined multiple miscarriage as two or more unsuccessful pregnancies, which would account for up to 5% of all miscarriages and this risk increases significantly after the age of 35.

There are some known causes of multiple miscarriage. However, despite many years of research, no explanation can be offered for over 50% of cases. Recent medical studies and genetic screening have proposed that certain gene variations in potential mothers are susceptibility factors that increase the risk of unexplained multiple miscarriage.

Blood supply is very important for a developing baby!

Blood carries oxygen and nutrients to different parts of our body. Successful pregnancies depend on good blood circulation to deliver these vital components to the placenta and the growing baby and the development of a healthy and functional vascular network is very important in the early stages of pregnancy. Recent studies have identified that inadequate blood vessel network formation may result in gestational complications, including growth restrictions, pregnancy loss and pre-eclampsia. Genetic analysis data from multiple miscarriage patients revealed a reduction in expressions of genes related to vasculature development.

Certain variations in your genes can increase the risk of multiple miscarriage.

Medical literature point to 3 blood vessels related genes: VEGF, p53 and eNOS as candidate markers in the pathology of unexplained multiple miscarriage. Recently, an article published in the medical journal Human Reproductive Update performed a systemic data analysis of all published investigations related to the involvement of these 3 genes in multiple miscarriages. The study showed that genetic variations in these genes were significantly and constantly associated with multiple miscarriage events.

If you have experienced multiple miscarriage and doctors cannot tell you why, we may be able to help…

In the current study, investigators concluded that VEGF, p53 and eNOS played important role in early pregnancies and are tied to multiple miscarriage. Genetic variations are being recognized as the underlying cause of multiple miscarriages. Recently, another study suggested that genetic variations in the gene PAI-1 is also linked to multiple miscarriages.

If you have experienced miscarriage and your physicians were not able to tell you why, it is time to take a deeper look into your genetic makeup.

Why is it a good time to try genetic screening? Advancement in genetic sequencing technology in the past decade has brought personalized medicine ever closer to the general population. The price tag of genome sequencing has dropped from 48,000 USD in 2009 to roughly 3,000 – 5,000 USD in present day. With our PregnaSeqTM service, not only will we screen your genome for deleterious markers associated with multiple miscarriage, but in the same test we will also look for:

  1. your carrier status for over 300 genetic diseases, determining the risk of heritable disease in your future children, and
  2. previously uncharacterized mutations in your genome that are potentially disease causing, therefore increasing the coverage of risk identification.

At GeneYouIn, we utilize up-to-date whole exome sequencing technologies as opposed to less efficient SNP genetic testing. We look for potential issues in your entire genetic sequence instead of searching only for commonly known disease-causing mutations. This way, results from our PregnaSeqTM service will give you a complete picture of your genetic well-being and also aid your physician in diagnosing unexplained fertility and pregnancy problems, providing both diagnostic and treatment options.

Please read our blogs for more informative content on fertility testing. If you have further questions, please feel free to call or email us.

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