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Many medications are not effective for some individuals, or cause adverse side effects: one example Tecta side effects and its failure to treat ulcers and heartburn. Tecta is a second generation drug used to treat heartburn and ulcers; the first generation drug being antihistamines. Tecta (pantoprazole) and other Proton Pump inhibitors (PPIs) are used in combination with an antibiotic and antihistamines. PPIs are a collection of drugs that acts to reduce gastric acid production. People who clear PPIs (lansoprazole, omeprazole, rabeprazole, esomeprazole) too fast are frequently unable to clear the infection and have to undergo multiple courses of treatment. If you are one of them you should know that this is a tat-a-tell sign for abnormal drug response that may have serious implications for your health, especially for Tecta side effects.
Ulcers are caused by Helicobacter pylori infections, which are more frequent in people in increased production of acid in the stomach. The triple therapy for ulcers is a combination of amoxicillin or tetracycline with metronidazole antibiotic, along with PPIs and/or histamine H2 blockers. PPIs work by blocking the production of stomach acid.
Why Tecta may be ineffective for ultra-fast metabolizers who have ulcers
PPIs, as all other drugs, are metabolized in liver and cleared out of the circulation. The CYP2C19 enzyme is responsible for metabolism of PPIs and other medications. Some individuals have mutations in the CYP2C19 gene that reduce the activity of this enzyme, so these people (poor and intermediate metabolizers) have higher levels of PPIs circulating in their blood at regular doses and clear H. pylori infections faster. However, fast CYP2C19 metabolizers clear the PPIs very efficiently and do not respond to triple therapy.
How Tecta side effects may affect you?
1. Find alternative medications for ulcers
If you did not respond to first PPI treatment there is a high chance that you are an ultra-fast metabolizer, so your physician should consider switching to other medications that are less affected by the CYP2C19 (lansoprazole and rabeprazole) and/or substantially increasing the dose of PPI.
You also should know that CYP2C19 is also metabolizing other medications and you will respond differently.
2. Response to Heart Medications
Ultra-fast CYP2C19 metabolizers treated with clopidogrel (aka Plavix) for heart disease, especially after stenting (i.e. a tube inserted into the body to open blood vessels in the heart), respond significantly better than average and have lower risk of heart attack or stroke. On the other hand, if you responded to PPIs very well because you are a poor CYP2C19 metabolizer, clopidogrel might be ineffective for you. Being an ultra-fast metabolizer does not always plays in your favor though…
3. Response to short-term anesthesia
If you are going for surgery, you may respond differently to short-term general anesthesia, particularly to specific benzodiazepines, which are frequently used to block short term memory to prevent unpleasant effects of surgery. One of our clients, who is an ultra-fast metabolizer, woke up in a middle of colonoscopy due to an ultra-fast clearance of diazepam. Conversely, poor metabolizers recover from diazepam-induced sleep much slower and are at increase risk of adverse side effects.
Conclusion – How to find out how you metabolize drugs
Your response to Tecta and other PPIs may inform you how you metabolize other medications, but additional liver enzymes clear other drugs, so you should check your broader metabolic profile through pharmacogenetic testing.
Want to learn more?
If you would like to learn more, please read this related blog post: I have stars in my genome! Or how genetic variations affect your drug response.
Learn more how PillCheck may help you to manage your medications.
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