PillCheck™ is your personalized dosing guide designed to be used by a pharmacogenetics-trained pharmacist to Personalize and Optimize your Treatment.

A simple non-invasive cheek swab can help your healthcare providers obtain insights into your drug metabolic profile.  It helps them to identify the most effective and safest treatment for you.  PillCheck covers over 65 commonly prescribed medications for the treatment of chronic conditions, including mental health, pain management and heart disease.

 “Why does PillCheck report on only 68 medications while other providers cover 400 drugs?”

To answer this question, let’s review the rationale underlying our selection of medications to include in the PillCheck Report.

In order to provide clinically relevant, actionable recommendations, and to ensure the adoption of PillCheck’s dosing recommendations by physicians, we have only selected medications that have well-defined pharmacogenetic guidelines for prescribing.

PillCheck’s drug-dosing guidelines are based on the following three sources of information:

  1. FDA, EMA and Health Canada drug labels, which are available for over 150 medications
  2. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines
  3. Royal Dutch Association for the Advancement of Pharmacy – Pharmacogenetics Working Group

Some details on each of the resources we use:

The US FDA drug labels are available for over 150 medications, with the majority mirrored by  EMA and Health Canada. About half of these drugs are used in cancer treatment, requiring a genetic test of tumor biopsy samples.  Since PillCheck uses a non-invasive cheek swab for sample collection, and is meant for people with chronic conditions, we do not report on the specialty medications for cancer treatment.

A limitation of FDA drug labels is that, although there are warnings about the possibility of high drug concentrations in people with reduced drug metabolism, frequently, there are no specific dosage guidelines.

In contrast, the CPIC and Dutch Pharmacogenetics Working Group provide specific dosing guidelines.

These guidelines form the basis of the recommendations in your PillCheck Report.

Our scientists review recommendations from all of the above sources to summarize the most pertinent information. With our unique software application, we build a personalized report for each patient.

We report only on drugs that have clear guidelines from the authorities listed above.

The PillCheck Report lists all markers tested, the functional classification of a client’s metabolic profile, the contribution of multiple genetic factors on (some) medications, and the references.

In contrast to the PillCheck Report, other providers tend to have a less transparent approach that can include the use of proprietary markers, the validity of which requires extensive clinical studies.  So far, only a few companies have validated their proprietary markers.

To justify the inclusion of markers/medications in their list, other companies may provide a published reference/report of a preliminary investigation based on a small group of subjects.  Such under-powered studies are rarely replicated, and are deemed to be insufficient for clinical implementation. The utilization of unproven claims to provide PGx recommendations would discourage healthcare providers from utilizing the advice.

When pharmacogenetic companies report on hundreds of medications, the clinical validity of the test should be verified.

PillCheck is a unique combination of broad clinical application and robust clinical validity, enabling healthcare providers to embrace this new technology to improve patient outcomes.

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